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[PubMed: 16904799] (Evaluation of the safety of oral ALA in rats who exhibited no evidence of toxicity except at the highest doses tested [121 mg/kg], which was associated with minor ALT elevations in males and slight changes in liver histology including small droplet fat in periportal regions, but without frank hepatocyte necrosis or inflammation)

Every recommendation for preserving lean muscle is guided by science, safety, and your individual health goals

Tom Biernacki, DPM Board-Certified Podiatrist, Balance Foot & Ankle Specialists, Michigan

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Mechanistic endpoints were recorded when available, including markers of inflammation, angiogenic activity, collagen organization, and bone remodeling