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Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use

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some intracellular testosterone is converted by 5-alpha reductase to the more potent dihydrotestosterone, whereas in adipose tissue a proportion aromatizes to estradiol, supporting skeletal maturation and feedback control of gonadotropins

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