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Important observations All five clinical trials that were included in the analysis reported GLP-1 receptor agonist-mediated reduction in substance use disorder, with two trials respectively reporting a significant therapeutic impact of GLP-1 receptor agonist in reducing alcohol use disorder and nicotine use disorder

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Timing Strategies for Taking Both Medications Safely The safest approach is consistent separation: take your birth control pill with breakfast and your GLP-1 injection on a different schedule, or take your oral tirzepatide/semaglutide dose at dinner when nausea is typically lower