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It stimulates the pancreas to produce insulin, preventing a rapid spike in blood sugar after meals

This happens because the silicone lubricant on the plunger can redistribute, especially in horizontal storage

In an accompanying manuscript, we extended these findings to humans without obesity (Gonzalez Trotter et al

Last reviewed: July 2, 2026 Last updated: July 2, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

notably, the proportion of patients with weight gain during the study was substantially higher in the placebo group