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As indicated earlier, retinol within the enterocytes is esterified to saturated fatty acids and packaged into chylomicrons

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This model entails that, upon androgen binding, AR is activated, loses interactions with chaperone proteins, translocates to the nucleus where it binds as a dimer to AREs and activates or represses transcription of its target genes with the assistance of a large interactome of regulatory proteins (Fig