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En caso de sobredosis, se debe iniciar un tratamiento de apoyo adecuado de acuerdo con las seales y sntomas clnicos del paciente

It is also notable that the titration schedules were preplanner and did not involve on-the-fly adjustments by participants or clinicians

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Smaller amounts of urine may appear if the kidneys are not making enough

Discussion MTX is a potentially toxic agent for the liver, 2 due to its activation of various pathways involving oxidative stress, inflammation, and both intrinsic and extrinsic apoptotic pathways - including pathways such as MAPK and p53