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His-tag does not necessarily enhance the solubility of expressed proteins, but is widely used for easy application for protein purification

In contrast, the FAT domain scaffold forms critical interactions with focal adhesion proteins and oncogenic receptor tyrosine kinases, mediating multiple signaling cascades for tumorigenesis, providing a potentially safe and effective therapeutic advantage over traditional kinase inhibition (Supplementary Fig

Overall, these results underline the multifaceted therapeutic promise of propolis across neurological, vascular, oncological, and wound-healing domains