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A low serum B12 level is the main clue, but it doesn't tell you why it's low
M.LawlorD
The decrease in rat brain GLUD1 activity with aging may be due to oxidative damage, as GLUD1 was shown to be inactivated by carbonylation (Opii et al., 2008), nitration (Bunik et al., 2016), or glycation (Hamelin et al., 2007)
The LXR receptor agonist T0901317 treatment dramatically promoted the expression and protein levels of ABCA1, which could be further boosted by PARP-1 knockdown, but even without LXR receptor agonist T0901317 treatment, PARP-1 knockdown alone also caused an increase in ABCA1 expression and protein level (Figures 5C,D)
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