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Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
It also has a real downside: roughly 40 percent of patients in the clinical trials reported nausea, with a meaningful number needing anti-nausea medication or stopping treatment because of it
Clin Biochem 1969
Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference
Large-scale human clinical trials have not yet been completed
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