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Interestingly, Glp1r was not produced by epithelial cells but rather by clusters of small cells primarily located within the lamina propria, consistent with previous findings 70

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To put these results into context, it is important to keep in mind that Liraglutide, 3 mg, branded as Saxenda for weight loss, prompts a mean body weight decrease of 8% compared to 2.6% for placebo about half of what 2.4 mg semaglutide (Wegovy) achieved in the general obese population

The therapeutic relevance of brain GLP-1 activity has expanded considerably with the widespread use of GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

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