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In vitro studies showed that DHLA in addition to Co 2+ , Ni 2+ , Cd 2+ , Cu 2+ , Zn 2+ , Pb 2+ , and Hg 2+ also chelates Fe 3+ (its complex is more stable than that formed with Fe 2+ ), whereas ALA preferentially binds Mn 2+ , Cu 2+, Zn 2+ , and Pb 2+ but cannot chelate Fe 3+ [ 14 , 15 ]

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Phase I safety studies report good tolerability with no serious adverse events at tested doses [9]

The Danish drugmakers shares have fallen nearly 45% this year, impacted by disappointing results from an Alzheimers trial and increasing competitive pressure from Lillys expanding GLP-1 footprint