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Researchers such as Roberts conducted a systematic analysis of hospitalized patients across 17 European countries between 1989 and 2015, revealing marked regional differences in the incidence of AP

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Pathogenic genetic variants in one of three genes encoding for amyloid precursor protein ( APP ), presenilin-1 or presenilin-2 lead to a form of the disease known as early-onset familial AD, which accounts for 510% of AD cases 1

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