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The daily dosing allows for more immediate adjustment if side effects become problematic

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In a post-hoc analysis of SURPASS-4 data, tirzepatide slowed the rate of decline in eGFR, showed clinically meaningful improvement in albuminuria and significantly lowered occurrence of the composite kidney outcomes compared to insulin glargine which may be related to SBP lowering [40]

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Appetite, digestion speed, and blood sugar regulation return to baseline, often causing hunger and cravings to reappear