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[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Jang S., Kim E.W., Zhang Y., Lee J., Cho S.Y., Ha J., Kim H., Kim E

This decline is one of the mechanisms behind the fatigue, cognitive slowing, and reduced physical resilience that patients often attribute to just getting older. A comprehensive review published in Cell Metabolism documenting the age-related decline in NAD levels and the downstream effects on mitochondrial function, cellular repair, and energy metabolism across tissue types

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The mTOR is a serine/threonine protein kinase, belonging to the phosphatidylinositol 3-kinase-related kinase family and it is widely known for its negative regulation of the autophagy process (Rabanal-Ruiz et al., 2017