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Aspartate had the largest abundance in SCC47 with dramatic fold change when compared to SCC9 (FC = 12.67, p = 0.021) and Detroit 562 (FC = 19.73, p = 0.017) (Fig

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Since 2010, it has technically remained the only truly FDA-approved treatment specifically indicated for the treatment of chronic migraine prevention, up until Qulipta (Atogepant) became the first and only pill to receive FDA approval for chronic migraine in 2023

The specific subclass of the IgG response also correlates with severity, with the potent immune-activating IgG1 and IgG3 (and particularly the combination of the two) being the most common in severe cases [181,182,183]

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