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This new paradigm began with the discovery of leptin, by Jeff Friedman and others in 1994, the first hormone whose primary function is the regulation of body weight, by signaling from the adipose tissue to pro-opiomelanocortin (POMC) neurons [6] in the hypothalamus to reduce food intake

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That pairing isn't arbitrary these two compounds operate on different parts of the same axis and produce a growth hormone pulse that neither can generate alone with the same magnitude or quality