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Ursolic acid (UA) is a natural pentacyclic triterpene derived from a great variety of traditional medicinal plants and most fruits and vegetables

An RDP study with 40 patients investigated the effects of 300 mg Pycnogenol supplementation per day for two months on subjects with chronic venous insufficiency (CVI) ( significantly relieved swelling (64%) and heaviness (54%) in the legs of CVI patients compared to placebo (7 and 3%, respectively)

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Not having sufficient levels of vitamin B12 can lead to health issues such as generalized weakness, numbness, leg stiffness, abnormal gait, memory loss, personality change, and a depressed mood