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Chemical modifications of protein include oxidation, deamidation, reduction, and hydrolysis (5)

Allow 30120 seconds for the powder to dissolve fully

Being the proximal tubule a major target for many nephrotoxicants, it is logical that cell-based in vitro models that seek to resemble this segment of the nephron should be characterized by the expression of important markers, including SLC22A6 (OAT1), SLC22A8 (OAT3), SLC22A2 (OCT2) on the basolateral membrane and ABCB1 (P-gp), SLC47A1 (MATE1), SLC47A2 (MATE2), ABCC2 (MRP2), ABCC4 (MRP4), ABCG2 (BCRP), and the endocytosis receptors megalin and cubilin on the apical membrane (Bajaj et al

If results are promising, the programme moves to Phase 3: larger, global, randomised trials involving, dependent on the indication hundreds to sometimes even thousands of participants, designed to confirm efficacy and build a robust safety profile