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However, long-term pharmacotherapy is required to maintain weight loss and cessation or withdrawal from therapy leads to weight regain even with continuing lifestyle intervention [4]

Preliminary studies in patients with T1DM and T2DM have shown that diabetes increases the urine ratio of lactobionate, and this may reflect the metabolic process of mitochondrial oxidation to glycolysis, which is reversed by SGLT2 inhibitors (Nespoux and Vallon, 2020)

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