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It predominantly localizes to the cellular membrane of diverse cell types throughout the human body

And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat

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When inflammation is high, especially in the liver (which plays a key role in hormone metabolism), estrogen can start to build up in the body instead of being properly cleared out

doi: 10.3748/WJG.V30.I23.2964 60 MacDonaldPEEl-kholyWRiedelMJSalapatekAMFLightPEWheelerMB