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Do not stop Rybelsus abruptly if: You have no alternative diabetes management plan in place Your diabetes is poorly controlled on Rybelsus (stopping will worsen control) You have not discussed discontinuation with your healthcare provider This structured approach ensures your diabetes remains well-managed throughout the transition period

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This disrupts mitochondrial membrane potential (MMP), leading to mitochondrial dysfunction, mitophagy dysregulation, neuroinflammation, and subsequent dopaminergic neuronal degeneration (Meng et al., 2025)