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For others, the safer first step may be labs, lifestyle counseling, treatment of sleep apnea, medication review, or addressing a medical driver of weight gain

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Chakraborty, S., Nazmi, A., Dutta, K

In the EMPA-REG study, empagliflozin significantly reduced the risk for the composite renal outcome, which included doubling of serum creatinine, progression of macroalbuminuria, initiation of renal replacement therapy, or renal death ( Subsequent studies, such as CREDENCE, DAPA-CKD, and EMPA-KIDNEY, were specifically designed to investigate the renoprotective effects of SGLT-2i

The focus of preclinical studies has shifted from investigating glucose metabolism alone to exploring more complex mechanisms, such as the metabolic interplay between Schwann cells and axons and the role of insulin resistance in nerve function