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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

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It is thought to influence the sleep-wake cycle by affecting neurotransmitter activity, including that of gamma-aminobutyric acid (GABA) and serotonin

Symptoms vary depending on the type of infection being treated and the individuals ability to process the release of toxins

Suzuki J, Jin Z-G, Meoli DF, Matoba T, Berk BC