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In all, mouse and rat models have significant limitations for the studies regarding CTSs, their effect on humans and their role in the pathogenesis of human diseases

Below, we will highlight some of the approaches (Fig

In this comprehensive article well explore what FOXO4-DRI is, how it works, the current pre-clinical evidence, its promise and limitations, comparisons with other senolytic approaches, safety and regulatory considerations, and what the future might hold for integrating this novel peptide into a clinical strategy for healthier ageing