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Because the compound simultaneously engages three separate receptor systems, researchers frequently observe that gastrointestinal tolerability markers (a common variable tracked in GLP-1-class research models) become the practical ceiling on titration speed long before receptor saturation is reached

10.1038/nature09486 Nature 132 LautenschgerJ.SchierleG

Nature 496(7443):101105 Sourbier C, Ricketts CJ, Liao PJ et al (2019) Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

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It also helps to support the production of collagen and soft tissues