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(2) Human microbiota transplantation models: germ-free mice transplanted with fecal microbiota from human DKD patients (HFA model) can more realistically simulate human microbiota-host interactions ( 3.2 Nutritional metabolic functions of the gut-liver axis 3.2.1 The portal venous system: the first station for nutrients The gut-liver axis establishes a direct anatomical connection between the intestine and liver through the portal venous system