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The limited success of targeted medication can be attributed to multiple factors, including cytokine interactions of this complex and convoluted system with immunological redundancy, translatability of animal models to humans, individual responses to therapy, and side effects of these therapeutic agents [1]

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This often-misdiagnosed condition affects the small, unmyelinated nerve fibers responsible for pain, temperature sensation, and autonomic functions, leading to symptoms that can range from mild discomfort to debilitating pain and dysfunction