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The intestine functions as a reward-sensing organ, peripheral physiology sets motivational drive, and central dopamine circuits are the final common pathway through which addiction is expressed

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These mechanistic pathways highlight a distinct advantage of microbiome-based interventions: they operate across multiple pathological domains immune signaling, mitochondrial stability, synaptic plasticity, and epigenetic regulation making them inherently multimodal when compared to traditional single-target drugs [163]

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Typical concentration: 50 mg/mL Choline Choline is an essential nutrient that serves as a building block for cell membranes and neurotransmitters