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Abstract Wilsons disease (WD) is a genetic disorder resulting from mutations in the ATP7B gene that lead to copper overload in hepatocytes

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So, a major portion of a dose of phenacetin would be rapidly metabolised to paracetamol, it seemed possible that phenacetin owed some of its antipyretic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methemoglobinemia) was due to another metabolite-phenetidine