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Further large-scale randomized controlled trials will be necessary to confirm their efficacy in diverse populations and explore their impact on DNA fragmentation and live birth rates

these observations corroborate the notion that specific subtle constraints must exist whereby a particular G6PD variant has a distinctly severe clinical expression but remains compatible with life

By enabling spatiotemporally controlled delivery, COFs can precisely transport immunomodulators to the core of the tumor battlefield, transforming initial immune signals into powerful effector responses

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