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A 2022 analysis in JAMA Internal Medicine , for example, found that the use of GLP-1 RAs was associated with an increased risk for gallbladder or biliary diseases, especially when used at higher doses, for longer durations, and for weight loss

When you eat, GLP-1 is released, prompting the pancreas to produce insulin, which helps lower blood glucose levels

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Additionally, the medication's appetite-suppressing effects may reduce overall fluid consumption