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Biofactors 2019;45:15268 6

In contrast, the SOUL trial, which enrolled a higher-risk population, showed a significant reduction in MACE with oral semaglutide [21]

Advanced technologies for differentiating kidney organoids from hPSCs and efficient genome-editing systems with the clustered regularly interspaced short palindromic repeat CRISPR-Cas9 have enabled modeling of human kidney diseases 15,16,17