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While lifestyle and genetics play roles, biological factors dominate

sphenanthera , has been shown to decrease APAP hepatotoxicity as well as to lead to features of liver regeneration by inhibiting NAPQI-initiated injury via the blockade of CYP activity, the down-regulation of p53/p21 and the up-regulation of other signaling pathways to facilitate hepatic tissue repair

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It was first discovered in human plasma and has since been found in saliva and urine