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The mechanism suggests it should
Because L-Citrulline largely bypasses first-pass liver metabolism (where some L-Arginine is broken down before reaching the bloodstream), research suggests that L-Citrulline may raise plasma L-Arginine levels more efficiently, gram for gram, than supplementing L-Arginine directly
Literature was searched in PubMed and Web of Science up to March 31, 2026, using combinations of terms including GLP-1 receptor agonist, semaglutide, liraglutide, tirzepatide, obesity, taste, flavour, dysgeusia, food preference, dietary intake, eating behaviour, appetite, satiety, food reward, craving, liking, wanting, and interoception. Studies were considered relevant if they addressed gustatory sensory function, hedonic food evaluation, food preference, dietary intake, cue-related food motivation, interoceptive modulation, or reward-related neural processing