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NFB is the most important transcription factor activating the expression of numerous pro-inflammatory cytokine genes such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF) each of which have been shown to be involved in promoting IR

Figure 3 4 Cirrhosis-related non-cholestatic pruritus 4.1 Prevalence and mechanisms Pruritus linked to liver ailments is particularly pronounced in chronic cholestatic liver conditions like primary biliary cholangitis and primary sclerosing cholangitis