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Wadwa RP, Reed ZW, Buckingham BA et al (2023) Trial of hybrid closed-loop control in young children with type 1 diabetes

While GLP-1s typically result in a 15%20% total body weight loss, bariatric procedures such as gastric sleeve and gastric bypass can help patients lose 60%80% of their excess weight , often translating to a 30%40% total body weight reduction

While no dose adjustment is required for chronic kidney disease, patients should be monitored for volume depletion due to gastrointestinal adverse effects and potential acute kidney injury risk

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Actions of metformin in the brain: a new perspective of metformin treatments in related neurological disorders