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When cysteine residues in KEAP1 undergo redox oxidation, NRF2 interacts with the Cul3/RING-box protein complex, ultimately leading to NRF2 ubiquitination and subsequent degradation via proteasomes

Reactive Oxygen Species (ROS) are increased by the consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake

Typical Research Dosing Guidelines Dosing is usually split once daily No human clinical data

Subsequently, Kuhn and collaborators confirmed the benefit of intravenous NADH

When applied to the skin, GHK-Cu stimulates key repair functions