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Proline at the third position is the key binding site of BPC157 for FBXO22 After confirming the critical role of FBXO22, we further investigated the interaction mechanism between BPC157 and FBXO22

Combination index (CI) was calculated using the CompuSyn software, CI 1.0 was defined as antagonism

One proposed mechanism is that lactate enhances hippocampal neuronal firing, potentially contributing to panic symptoms ( Holdemanella has been associated with reduced right amygdala and hippocampal volumes (Wanapaisan et al., 2022) brain regions consistently reduced in PTSD individuals ( Additional population studies have expanded these findings