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Some patients may benefit from a gradual dose increase, while others simply need to improve protein intake, hydration, strength training, or sleep quality

Its way more effective, Anekwe told The Nations Health , noting that her patients achieved significantly greater weight loss with GLP-1 medications compared to diet and lifestyle changes alone

The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

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But the weight always came back