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While current biomarkers remain preclinical, their clinical adoption requires rigorous validation across diverse populations and standardized implementation

The number of labeled RGCs was obtained from one central (0.1 mm from the optic disc), one middle (0.8 mm from the optic disc), and one peripheral (1.5 mm from the optic disc) areas (0.04 mm 2 ) per quadrant of each retina, and expressed as number per square millimeter 11,49,53,83

to perform in vivo experiments