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The transcription of a set of genes related to the regulation of heme synthesis and transformation, such as heme oxygenase 1 (HO-1), ferrochelatase (FECH) and SLC48A1, is upregulated by NRF2 [100,101,102,103]

437 In type 2 diabetic rats, more mtDNA injury and less mtDNA copy number were observed in retinal microvessels

and Watkins, J.C

To carry out in vivo studies, pure HTyr was prepared by different synthetic methods starting from commercially available compounds such as 3,4-dihydroxyphenylacetic acid [52] or tyrosol using chemical or enzymatic procedures [53,54,55,56]