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Xiao M, Zhang Y, Zhang X, Zhang G, Jin C, Yang J, et al

The estimation of half-life is done for three experimental models namely: yeast in vivo , mammalian reticulocytes (immature red blood cells) in vitro and Escherichia coli in vivo [39]

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To figure out what was blocking it, they looked for proteins that were being generated in higher numbers than normal in the cell that might be jamming up the works of the apoptosis mechanisms