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GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants

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Notably, genes promoting glutathione biosynthesis were broadly upregulated, whereas genes associated with glutathione consumption or turnover were comparatively reduced ( Figure 6B )

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The Western blot analysis confirmed that T315I-Bcr-Abl-32D cells clearly expressed higher level of ATF4 (Fig