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& Rabinovitch, P

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As outlined above, studies on non-glutathione disulfide substrates unfortunately regularly lack more detailed kinetic analyses, first, to confirm the efficient turnover of the substrate candidates and, second, to validate the dithiol mechanism

In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

doi: 10.1523/JNEUROSCI.6078-08.2009 95 KangH