Thus, we implemented the following sensitivity analyses: 1) the Q test was carried out with the IVW and MREgger methods to detect possible violations of the hypothesis by the heterogeneity of the correlation between individual IVs ( 2.6 Genetic correlation and direction validation MR analysis may violate cause-effects under the premise of genetic correlation between the exposure and outcome of the research ( 2.7 Metabolic pathway analysis Metabolic pathways were estimated using Web-based metconflict 5.0 ( ( 2.8 Intersection analysis An intersection analysis was introduced to analyse the shared metabolites screened by the forward and reverse MR analyses and, in conjunction with potential pathway mechanisms, to evaluate the relationship between metabolic pathways and circulatory deterioration in SLE
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