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Concerns about potential safety and efficacy issues have turned the peptide into a kind of gray-market celebrity, where consumer safety and efficacy are almost certainly a risk

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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]