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Cell-culture research has shown that reducing NNMT was associated with less lipid accumulation in fat cells, while increasing NNMT was associated with more suggesting NNMT contributes to adipocyte function rather than simply marking metabolic dysfunction

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Discussion Across rodent and cell models, NNMT inhibition acts as a metabolic re-allocator, simultaneously relieving a methyl sink and diverting nicotinamide back to NAD salvage