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Description

The finding of distinct central populations of Gipr -expressing neurones in the AP and hypothalamus underlying responses to agonism and antagonism, respectively, goes some way towards resolving the dilemma of agonism and antagonism having similar outcomes

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Phase 3 trials are ongoing and no version is approved for prescription use in the UK

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Common side effects include gastrointestinal symptoms, with berberine potentially interacting with diabetes medications and drugs metabolised by CYP enzymes

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Subcutaneous delivery offers advantages including patient self-administration, consistent absorption, and reduced healthcare system burden

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