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That spot is most likely a labial melanotic macule, the most common pigmented lesion of the lip

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[7] [8] However, much of the mechanistic evidence underpinning these effects remains preclinical or derived from early-phase studies, and definitive human data are still awaited

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9,11 Among GLP-1 agonists, only liraglutide is currently FDA-approved for weight-loss in non-diabetic patients

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