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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

Melatonin may potentiate this effect

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Future work focusing on a more thorough evaluation of the skeletal phenotypes of these animals will be of interest to the bone research community

This focus on height originally reflected a measure of successful GH replacement therapy (GHRT) after which treatment was ended